Genetics and Bipolar Disorder: Is it Inherited?

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Bipolar disorder is a complex psychiatric condition, and its exact cause is not fully understood. Research currently suggests that genetics play a significant role in the development of bipolar disorder, but it is not the sole factor contributing to the condition. How do genetics play a role, and what are some other causes of bipolar disorder?

Bipolar Genetics

Genetics is typically first on the list of factors people look at when wondering where a condition comes from. Biological factors often have a heavy influence on whether a person develops a range of physical and mental health conditions, and this is no different for bipolar disorder. There are multiple facets of the bipolar genetics component.1

Family History

Bipolar disorder tends to run in families, suggesting a genetic component. If you have a close family member (e.g., parent or sibling) with bipolar disorder, your risk of developing the condition is higher than the general population.

Genetic Studies

Research has identified specific genes that may be associated with bipolar disorder, although it is a polygenic condition, meaning that multiple genes are likely involved. These genes are believed to influence neurotransmitter function, neural pathways, and other aspects of brain function.

Neurochemical Imbalance

Bipolar disorder is often associated with imbalances in neurotransmitters such as serotonin, dopamine, and norepinephrine, which play a crucial role in mood regulation. Genetic factors may contribute to these imbalances.

Brain Structure and Function

Some studies have shown differences in the structure and function of the brain in individuals with bipolar disorder. These differences may have a genetic basis or could be influenced by environmental factors.

Other Causes of Bipolar Disorder

Genetics is not the only thing responsible for bipolar disorder development. There are a few other factors and causes of bipolar disorder.

Environmental Factors

Stress: Stressful life events, trauma, or chronic stress can trigger episodes of bipolar disorder in genetically predisposed individuals.

Substance Abuse

Substance abuse, including alcohol and drug misuse, can exacerbate bipolar symptoms and may interact with genetic factors to increase the risk of the disorder.


Some medications, such as antidepressants or corticosteroids, can trigger manic or depressive episodes in people with a genetic predisposition to bipolar disorder.

Biological Clock and Circadian Rhythms

Disruptions in circadian rhythms and the body’s internal biological clock may contribute to mood swings in bipolar disorder. Genetic factors may influence an individual’s susceptibility to these disruptions.

Hormonal Changes

Hormonal fluctuations, such as those occurring during puberty, pregnancy, or menopause, can influence the onset or severity of bipolar episodes.

Infections and Immune System

Some research suggests that infections and immune system dysfunction may be associated with bipolar disorder, although the mechanisms are not fully understood.

Treating Bipolar Disorder

It’s essential to recognize that bipolar disorder is a complex interplay of genetic, environmental, and neurobiological factors. Having a family history of the disorder does not guarantee that an individual will develop it, and many people with bipolar disorder do not have a family history of the condition. 

Although there is no cure for bipolar disorder, treatment can help manage the condition.2 Diagnosis and treatment typically involve a combination of genetic, clinical, and environmental factors to determine the best approach. Specialized facilities like Clearview Treatment Programs develop individualized treatment plans that consider your unique needs when you arrive. If you’re ready to reach out for help, call us at 310-455-5258 or submit an online contact form today.


  1. National Institute of Mental Health. (2022). Bipolar Disorder.
  2. Substance Abuse and Mental Health Services Administration. (2023). The risks of social isolation.

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